Solid-self-emulsifying drug delivery system (S-SEDDS) of paclitaxel (Ptx) was developed by the spray drying method with the\npurpose of improving the low bioavailability (BA) of Ptx. 10% oil (ethyl oleate), 80% surfactant mixture (Tween 80 : Carbitol, 90 : 10,\nw/w), and 10% cosolvent (PEG 400) were chosen according to their solubilizing capacity.Themean droplet size, zeta potential, and\nencapsulation efficiency of the prepared S-SEDDS were 16.9 �± 1.53 nm, 12.5 �± 1.66mV, and 56.2 �± 8.1%, respectively. In the S-SEDDS,\nPtx presents in the form of molecular dispersion in the emulsions or is distributed in an amorphous state or crystalline with very\nsmall size. The prepared S-SEDDS formulation showed 70 and 75% dissolution in 60 and 30 min in dissolution medium pH 1.2\nand 6.8, respectively. Significant increase (
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